β,N,N-Trimethylphenethylamine

β,N,N-Trimethylphenethylamine
Clinical data
Other namesN,N-Dimethyl-2-phenylpropan-1-amine; N,N-DMPPA; DMPPA; β,N,N-TMPEA
Identifiers
  • N,N-dimethyl-2-phenylpropan-1-amine
CAS Number
PubChem CID
ChemSpider
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC11H17N
Molar mass163.264 g·mol−1
3D model (JSmol)
  • CC(CN(C)C)C1=CC=CC=C1
  • InChI=1S/C11H17N/c1-10(9-12(2)3)11-7-5-4-6-8-11/h4-8,10H,9H2,1-3H3
  • Key:JFNWQFWYAAPODB-UHFFFAOYSA-N

β,N,N-Trimethylphenethylamine, also known as N,N-dimethyl-2-phenylpropan-1-amine (N,N-DMPPA or DMPPA) is a monoamine releasing agent of the phenethylamine family.[1] It is the N-methyl derivative of phenpromethamine (β,N-methylphenethylamine) and the N,N-dimethyl derivative of β-methylphenethylamine.[1] The drug is a partial norepinephrine releasing agent, with an EC50Tooltip half-maximal effective concentration of 1,337 nM and an EmaxTooltip maximal efficacy of 67% in rat brain synaptosomes.[1] Conversely, it was inactive on dopamine, whereas serotonin was not reported.[1] The drug produces non-significant increases in blood pressure in rodents, but does not affect heart rate or affect locomotor activity.[1] It may be rapidly metabolized and thereby inactivated.[1] DMPPA was first described in the scientific literature by at least 2019.[1]

See also

References

  1. ^ a b c d e f g Schindler CW, Thorndike EB, Rice KC, Partilla JS, Baumann MH (June 2019). "The Supplement Adulterant β-Methylphenethylamine Increases Blood Pressure by Acting at Peripheral Norepinephrine Transporters". The Journal of Pharmacology and Experimental Therapeutics. 369 (3): 328–336. doi:10.1124/jpet.118.255976. PMC 6533570. PMID 30898867.
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